Article

Phosphorylation regulates tau’s phase separation behavior and interactions with chromatin

2023-12-23

Abstract excerpt

Tau is a microtubule-associated protein often found in neurofibrillary tangles (NFTs) in the brains of patients with Alzheimer’s disease (AD). Beyond this context, mounting evidence suggests that tau localizes into the nucleus, where it may play a role in DNA protection and heterochromatin regulation. Models of tau depletion or pathology show loss of genetically silent heterochromatin, aberrant expression of heter...

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Literature Corpus work: 8c3736ea-2eeb-53fb-974f-94b086f3d31b
DOI: 10.1101/2023.12.21.572911

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