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Article

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.

The Journal of pathology - 1 Nov 2016

Maguire Sarah L, Peck Barrie, Wai Patty T, Campbell James, Barker Holly, Gulati Aditi, Daley Frances, Vyse Simon, Huang Paul, Lord Christopher J, Farnie Gillian, Brennan Keith, Natrajan Rachael

Abstract excerpt

The initiation and progression of breast cancer from the transformation of the normal epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process involving the acquisition of genetic alterations and changes in gene expression, alongside microenvironmental and recognized histological alterations. Here, we sought to comprehensively characterise the genomic and transcriptomic features of...

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Topics

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Share to Carcinoma, Ductal, Breast
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Class I Phosphatidylinositol 3-Kinases

Share to DNA, Neoplasm

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Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 27512948
DOI: 10.1002/path.4778
PMCID: PMC5082563

Genes

HRAS
MYC
UBA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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