Article

Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancer

2025-08-01

Abstract excerpt

Cellular plasticity enables cancer cells to escape therapy by adopting stem-like or alternate lineage states. Here, we identify a mechanism by which cannabinoid receptor 2 (CB2R) activation promotes irreversible lineage commitment in breast cancer. Using patient-derived and murine organoids, we show that brief, low-dose exposure to CB2R agonists—either phytogenic or synthetic—induces a basal-to-luminal transition,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d8c71a4-8704-5e1e-97ae-547c1d81ffad
DOI: 10.1101/2025.07.29.667375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancerDOI 10.1101/2025.07.29.667375Read

Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin openingSemantic proximity Read

Rare somatic cells from human breast tissue exhibit extensive lineage plasticitySemantic proximity Read

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast CancerSemantic proximity Read

Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancerSemantic proximity Read

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriersSemantic proximity Read

An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.Semantic proximity Read

Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin openingSemantic proximity Read

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtypeSemantic proximity Read

BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer.Semantic proximity Read

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage DifferentiationSemantic proximity Read

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation.Semantic proximity Read

Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.Semantic proximity Read