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BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CA <sup>H1047R</sup> oncogene

2023-07-27

Abstract excerpt

Single cell transcriptomics studies have begun to identify breast epithelial cell and stromal cell specific transcriptome differences between BRCA1/2 mutation carriers and non-carriers. We generated a single cell transcriptome atlas of breast tissues from BRCA1, BRCA2 mutation carriers and compared this single cell atlas of mutation carriers with our previously described single cell breast atlas of healthy non-car...

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Literature Corpus work
39415b76-1140-51dc-bb70-990c84720d54
DOI
10.1101/2023.07.26.550741
Open publication

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BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CA <sup>H1047R</sup> oncogeneDOI 10.1101/2023.07.26.550741
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