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Evolutionary Conservation of Human DNA Methyltransferase 3 Alpha (Dnmt3a) Gene in Acute Myeloid Leukemia (Aml): A Computational Study

2026-08-18

Abstract excerpt

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy characterized by the abnormal proliferation of myeloid precursor cells and disrupted haematopoiesis. The DNA methyltransferase 3 alpha (DNMT3A) gene is a key epigenetic regulator involved in DNA methylation and hematopoietic differentiation, and its mutations are among the most common genetic alterations observed in AML. This study investigat...

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Literature Corpus work: 03db535f-e606-5ba6-8c74-82f35a1b585a
DOI: 10.56201/jbgr.vol.12.no4.2026.pg27.39

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