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The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia.

Cancer medicine - 1 May 2023

Chen Xian, Tian Chuchu, Hao Zhuanghui, Pan Lingang, Hong Minglin, Wei Wei, Muyey Daniel Muteb, Wang Hongwei, Chen Xiuhua

Abstract excerpt

To refine the biological and prognostic significance of DNMT3A mutations in acute myeloid leukemia (AML), we assessed the impact of DNMT3A variant allele frequency (VAF) and its comutations in this study. Using targeted next-generation sequencing, we analyzed 171 adult patients with de novo cytogenetically normal AML for DNMT3A mutations and associated comutations. DNMT3Amut was detected in 35 patients. DNMT3Amut...

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Identifiers

PMID: 36912186
DOI: 10.1002/cam4.5764
PMCID: PMC10225240

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