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Article

Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.

BioMed research international - 1 Jan 2020

Chen Shuyi, Chen Yimin, Lu Jielun, Yuan Danyun, He Lang, Tan Huo, Xu Lihua

Abstract excerpt

BACKGROUND: DNA methyltransferase 3 alpha (DNMT3A) mutation was one of the most frequent genetic alterations in acute myeloid leukemia (AML), which was associated with poor prognosis and appeared to be a potential biomarker. Herein, we aimed to identify the key genes and pathways involved in adult AML with DNMT3A mutations and to find possible therapeutic targets for improving treatment. METHODS: The RNA...

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Share to Computational Biology
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Protein Interaction Mapping

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Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 33299888
DOI: 10.1155/2020/9321630
PMCID: PMC7707947

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