Article

Complementary modes of resistance to <i>EGFR</i> TKI in lung adenocarcinoma through MAPK activation and cellular plasticity

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> EGFR -mutant lung adenocarcinoma (LUAD) represents 20% of all non-small cell lung carcinomas, with most patients presenting with incurable metastatic disease. Treatment with mutant-selective EGFR tyrosine kinase inhibitors (TKIs) results in initial tumor reduction, yet nearly all patients eventually relapse. The mechanisms driving drug resistance are incompletely understood, creating significan...

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Literature Corpus work: 163aaa57-7967-5c77-b93c-7a5591b95a06
DOI: 10.1101/2025.05.07.652714

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