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Article

Potent Cas9 inhibition in bacterial and human cells by new anti-CRISPR protein families

2018-06-20

Abstract excerpt

CRISPR-Cas systems are widely used for genome engineering technologies, and in their natural setting, they play crucial roles in bacterial and archaeal adaptive immunity, protecting against phages and other mobile genetic elements. Previously we discovered bacteriophage-encoded Cas9-specific anti-CRISPR (Acr) proteins that serve as countermeasures against host bacterial immunity by inactivating their CRISPR-Cas sy...

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Literature Corpus work
03b2eb24-b48b-5769-948b-6d78b0ee473b
DOI
10.1101/350504
Open publication

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