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Article

Diversity of CRISPR-Cas immune systems and molecular machines.

Genome biology - 9 Nov 2015

Barrangou Rodolphe

Abstract excerpt

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

Topics

Adaptive Immunity
Animals
Bacteria
CRISPR-Cas Systems
DNA
Genetic Engineering
Genetic Variation
Humans
RNA Editing

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26549499
DOI: 10.1186/s13059-015-0816-9
PMCID: PMC4638107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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