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Metagenomic discovery of novel CRISPR-Cas13 systems

11 Oct 2022

Abstract excerpt

CRISPR-Cas systems are crucial adaptive immune components of microbial resistance against the invasion of mobile genetic elements (MGEs) and serve as the core of current cutting-edge genome engineering technologies 1 . Unlike the widely applied Cas9 or Cas12 DNA editing tools in present use, Cas13 is an RNA-guided programable RNA-targeting single effector system that enables gene manipulation at the...

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PMID: 36220832
DOI: 10.1038/s41421-022-00464-5

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