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Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants

27 Aug 2018

Abstract excerpt

The genetic architecture of late-onset Alzheimer disease (AD) in African Americans (AAs) differs from that in persons of European ancestry. In addition to APOE, genome-wide association studies (GWASs) of AD in AA samples have implicated ABCA7, COBL, and SLC10A2 as AA-AD risk genes. Previously, we identified by whole exome sequencing a small number of AA AD cases and subsequent genotyping in a large AA sample of...

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PMID: 30210277
DOI: 10.3389/fnins.2018.00592

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