Article
Biology of splicing in Alzheimer's disease research.
Progress in molecular biology and translational science - 1 Jan 2019
Nagata Kenichi, Saito Takashi, Saido Takaomi C, Morihara Takashi
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disease, leading to dementia in the aging human brain. Although a huge amount of research has been done to date, the pathogenesis of AD remains largely unknown. Given the dominance of mRNA splicing in the nervous system, it would be invaluable to precisely identify mis-splicing in the AD brain to understand more deeply how the gene network orchestrates...
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