Article

Allele-specific splicing modulates protein isoforms and Alzheimer’s risk

2026-02-16

Abstract excerpt

Despite growing catalogs of genetic variation linked to human traits and diseases, the functional impact of most genetic variants remains poorly understood. Alternative splicing, particularly in the human brain, represents a key layer of post-transcriptional regulation that may mediate genetic effects on gene expression and protein diversity. In this study, we systematically map allele-specific alternative splicin...

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Literature Corpus work: da1da95b-a1bd-52ac-84a9-d575b6639d5c
DOI: 10.64898/2026.02.13.705796

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