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Article

A splicing transcriptome-wide association study identifies novel altered splicing for Alzheimer's disease susceptibility.

Neurobiology of disease - 1 Aug 2023

Sun Yanfa, Bae Ye Eun, Zhu Jingjing, Zhang Zichen, Zhong Hua, Yu Jie, Wu Chong, Wu Lang

Abstract excerpt

Alzheimer's disease (AD) is a common neurodegenerative disease in aging individuals. Alternative splicing is reported to be relevant to AD development while their roles in etiology of AD remain largely elusive. We performed a comprehensive splicing transcriptome-wide association study (spTWAS) using intronic excision expression genetic prediction models of 12 brain tissues developed through three modelling...

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PMID: 37354922
DOI: 10.1016/j.nbd.2023.106209

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