Article

Models of SIV rebound after treatment interruption that involve multiple reactivation events

2020-07-29

Abstract excerpt

In order to assess the efficacy of novel HIV-1 treatments leading to a functional cure, the time to viral rebound is frequently used as a surrogate endpoint. The longer the time to viral rebound, the more efficacious the therapy. In support of such an approach, mathematical models serve as a connection between the size of the latent reservoir and the time to HIV-1 rebound after treatment interruption. The simplest...

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Literature Corpus work: 0386f5d7-d1b0-52af-adb6-ce54634f9b28
DOI: 10.1101/2020.07.28.221226

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