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Article

Establishment of latent HIV-1 reservoirs: what do we really know?

1 Jan 2019

Abstract excerpt

Despite our ability to suppress HIV-1 replication indefinitely in people on optimal combined antiretroviral therapy (cART), HIV-1 persists as a stably integrated and replication-competent provirus in a heterogeneous collection of long-lived cells (often referred to as 'latent reservoirs') in all individuals on treatment. Reactivation of these latent proviruses is believed to be responsible for the rebound...

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PMID: 30800420
DOI: 10.1016/s2055-6640(20)30275-2

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