HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study.

doi:10.1016/j.ebiom.2026.106411

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study.

EBioMedicine - 1 Sept 2026

Lungu Cynthia, Hossain Tanvir, Crespo Raquel, Prins Henrieke A B, Hensley Kathryn S, Rokx Casper, Rao Shringar, van Kampen Jeroen J A, van de Vijver David A M C, Mesplède Thibault, Katsikis Peter D, Gruters Rob A, Mueller Yvonne M, Mahmoudi Tokameh

Abstract excerpt

BACKGROUND: Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment. While short-term dynamics of HIV-1 rebound following treatment interruption have been extensively studied, the longer-term consequences of immune perturbation and transient viraemia for reservoir quality and immune architecture remain...

Read the complete abstract on PubMed

Topics

Humans
HIV-1
HIV Infections
Treatment Interruption
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Follow-Up Studies

Viral Load

CD4-Positive T-Lymphocytes

Female

Male

Virus Replication

Dendritic Cells

Anti-HIV Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 42541927
DOI: 10.1016/j.ebiom.2026.106411
PMCID: PMC13453597

Genes

CXCR3
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study.PMID 42541927Read ↗

HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond.Semantic proximity Read ↗

Dynamics of HIV reservoir decay and naïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatmentSemantic proximity Read ↗

Reservoir and Phylogenetic Signatures Identify Distinct Subsets of HIV-1 Nonsuppressible ViremiaSemantic proximity Read ↗

HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollersSemantic proximity Read ↗

Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy.Semantic proximity Read ↗

Phenotypic signatures of immune selection in HIV-1 reservoir cells.Semantic proximity Read ↗

HIV superinfection reveals sequential reservoir reactivation and immune-driven rebound dynamicsSemantic proximity Read ↗

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption.Semantic proximity Read ↗

Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infectionSemantic proximity Read ↗

Longitudinal transcriptomic analysis of SIV-infected rhesus macaques reveals peripheral immune dynamics throughout untreated SIV infection and long-term antiretroviral therapySemantic proximity Read ↗

Persistence of an intact HIV reservoir in phenotypically naive T cells.Semantic proximity Read ↗

Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.