Article
HIV rebounds from latently infected cells, rather than from continuing low-level replication.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2008
Joos Beda, Fischer Marek, Kuster Herbert, Pillai Satish K, Wong Joseph K, Böni Jürg, Hirschel Bernard, Weber Rainer, Trkola Alexandra, Günthard Huldrych F
Abstract excerpt
Rapid rebound of plasma viremia in patients after interruption of long-term combination antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid reactivation of latently infected cells. To further characterize rebounding virus, we performed extensive longitudinal clonal evolutionary studies of HIV env C2-V3-C3 regions and exploited the temporal relationships of rebounding plasma...
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