Article
Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy.
Journal of virology - 1 Feb 2016
Kearney Mary F, Wiegand Ann, Shao Wei, Coffin John M, Mellors John W, Lederman Michael, Gandhi Rajesh T, Keele Brandon F, Li Jonathan Z
Abstract excerpt
UNLABELLED: Understanding the origin of HIV variants during viral rebound may provide insight into the composition of the HIV reservoir and has implications for the design of curative interventions. HIV single-genome sequences were obtained from 10 AIDS Clinical Trials Group participants who underwent analytic antiretroviral therapy (ART) interruption (ATI). Rebounding variants were compared with those in pre-ART...
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