Article

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease

2024-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (“the reservoir”) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people with HIV (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir decay from peripheral CD4+ T cells. Nonlinear generalized additive models demonstrated rapid biphasic decay...

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Literature Corpus work: e9ee73a5-1125-5af5-82f6-9ad0c03bb713
DOI: 10.1101/2024.03.27.24304867

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