Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

5 Jul 2017

Abstract excerpt

The kinetics of HIV-1 decay under treatment depends on the class of antiretrovirals used. Mathematical models are useful to interpret the different profiles, providing quantitative information about the kinetics of virus replication and the cell populations contributing to viral decay. We modeled proviral integration in short- and long-lived infected cells to compare viral kinetics under treatment with and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28678879
DOI: 10.1371/journal.ppat.1006478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integrationPMID 28678879Read ↗

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV diseaseSemantic proximity Read ↗

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV DiseaseSemantic proximity Read ↗

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapySemantic proximity Read ↗

A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In VivoSemantic proximity Read ↗

Dynamics of HIV reservoir decay and naïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatmentSemantic proximity Read ↗

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeSemantic proximity Read ↗

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistenceSemantic proximity Read ↗

Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimenSemantic proximity Read ↗

Mathematical approaches in the study of viral kinetics and drug resistance in HIV-1 infection.Semantic proximity Read ↗

Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwardsSemantic proximity Read ↗

Models of SIV rebound after treatment interruption that involve multiple reactivation eventsSemantic proximity Read ↗

Stable HIV-1 integrase diversity during initial HIV-1 RNA decay suggests complete blockade of plasma HIV-1 replication by effective raltegravir-containing salvage therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.