Article

Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy

2026-08-10

Abstract excerpt

Rubicon is a negative regulator of autophagy and the endolysosomal network (ELN) and an antagonist of the class III phosphatidylinositol 3-kinase complex II (PI3KC3-C2). Inhibition of Rubicon is considered a potential means to therapeutically upregulate autophagy and the ELN to treat Parkinson’s disease and other conditions characterized by autophagic and ELN dysfunction. Rubicon is specific for the UVRAG-containi...

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Literature Corpus work: 035f53e7-2dee-5bb6-8f87-16a3c31b9ad7
DOI: 10.64898/2026.08.07.743589

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