Article

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

2019-11-12

Abstract excerpt

The autophagy-initiating human ULK complex consists of the kinase ULK1/2, FIP200, ATG13, and ATG101. Hydrogen-deuterium exchange mass spectrometry was used to map their mutual interactions. The N-terminal 640 residues (NTD) of FIP200 interact with the C-terminal IDR of ATG13. Mutations in these regions abolish their interaction. Negative stain electron microscopy (EM) and multiangle light scattering showed that FI...

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Literature Corpus work: f5a5bf27-a19c-53af-ac75-91d3f0c8ba47
DOI: 10.1101/840009

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