Article
Crystallographic Characterization of ATG Proteins and Their Interacting Partners.
Methods in enzymology - 1 Jan 2017
Qiu Y, Zheng Y, Taherbhoy A M, Kaiser S E, Schulman B A
Abstract excerpt
Autophagosome formation and specific substrate recruitment during autophagy require ligation of the ubiquitin-like protein (UBL) Atg8 to the head group of the lipid phosphatidylethanolamine. Atg8 lipidation is mediated by distinctive UBL cascades involving autophagy-specific E1, E2, and E3 enzymes that differ substantially in sequence from components of other UBL conjugation cascades. Structural studies are...
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