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Article

Rubicon: LC 3‐associated phagocytosis and beyond

7 Dec 2017

Abstract excerpt

Rubicon (Rubcn) was initially identified as a component of the Class III PI3K complex and a negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon has attracted the most notoriety because of its critical role in LC3-associated phagocytosis (LAP), a form of noncanonical autophagy that utilizes some components of the autophagy machinery to process extracellular cargo. Additionally,...

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Share to Autophagy in Disease and Therapy
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Identifiers

PMID: 29215797
DOI: 10.1111/febs.14354

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