Article

Architecture of the Tuberous Sclerosis Protein Complex

2020-10-01

Abstract excerpt

The Tuberous Sclerosis Complex (TSC) protein complex (TSCC), comprising TSC1, TSC2, and TBC1D7, is widely recognised as a key integration hub for cell growth and intracellular stress signals upstream of the mammalian target of rapamycin complex 1 (mTORC1). The TSCC negatively regulates mTORC1 by acting as a GTPase-activating protein (GAP) towards the small GTPase Rheb. Both human TSC1 and TSC2 are important tumour...

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Literature Corpus work: 21aa2462-c4f3-55d2-8472-181018669940
DOI: 10.1101/2020.09.29.319707

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