Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Architecture of the Tuberous Sclerosis Protein Complex.

Journal of molecular biology - 22 Jan 2021

Ramlaul Kailash, Fu Wencheng, Li Hua, de Martin Garrido Natàlia, He Lin, Trivedi Manjari, Cui Wei, Aylett Christopher H S, Wu Geng

Abstract excerpt

The Tuberous Sclerosis Complex (TSC) protein complex (TSCC), comprising TSC1, TSC2, and TBC1D7, is widely recognised as a key integration hub for cell growth and intracellular stress signals upstream of the mammalian target of rapamycin complex 1 (mTORC1). The TSCC negatively regulates mTORC1 by acting as a GTPase-activating protein (GAP) towards the small GTPase Rheb. Both human TSC1 and TSC2 are important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryoelectron Microscopy
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Protein Interaction Domains and Motifs

Share to Recombinant Proteins

Share to Structure-Activity Relationship

Share to Tuberous Sclerosis Complex 1 Protein

Share to Tuberous Sclerosis Complex 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 33307091
DOI: 10.1016/j.jmb.2020.166743
PMCID: PMC7840889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Architecture of the Tuberous Sclerosis Protein Complex.PMID 33307091Read ↗

Architecture of the Tuberous Sclerosis Protein ComplexSemantic proximity Read ↗

Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

Structure of the human TSC:WIPI3 lysosomal recruitment complex.Semantic proximity Read ↗

New insights into tuberous sclerosis complex: from structure to pathogenesisSemantic proximity Read ↗

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis PathogenesisSemantic proximity Read ↗

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.Semantic proximity Read ↗

Evolution of growth factor signaling to the TSC complex to regulate mTORC1Semantic proximity Read ↗

Structural Insights into TOR SignalingSemantic proximity Read ↗

The dual role of the TSC complex in cancer.Semantic proximity Read ↗

Genetics and Molecular Biology of Tuberous Sclerosis ComplexSemantic proximity Read ↗

Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex AssemblySemantic proximity Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.