Variant-specific priors clarify colocalisation analysis.

Abstract excerpt

Linking GWAS variants to their causal gene and context remains an ongoing challenge. A widely used method for performing this analysis is the coloc package for statistical colocalisation analysis, which can be used to link GWAS and eQTL associations. Currently, coloc assumes that all variants in a region are equally likely to be causal, despite the success of fine-mapping methods that use additional information...

Topics

• Quantitative Trait Loci
• Genome-Wide Association Study
• Humans
• Polymorphism, Single Nucleotide
• Models, Genetic
• Computer Simulation
• Chromosome Mapping