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Article

Colocalization of GWAS and eQTL Signals Detects Target Genes.

American journal of human genetics - 1 Dec 2016

Hormozdiari Farhad, van de Bunt Martijn, Segrè Ayellet V, Li Xiao, Joo Jong Wha J, Bilow Michael, Sul Jae Hoon, Sankararaman Sriram, Pasaniuc Bogdan, Eskin Eleazar

Abstract excerpt

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual's disease risk through their effect on gene expression in different tissues. In order to understand the mechanisms driving a GWAS risk locus, it is helpful to determine which gene is affected in specific tissue types. For example,...

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PMID: 27866706
DOI: 10.1016/j.ajhg.2016.10.003
PMCID: PMC5142122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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