Article

Mutated neuronal voltage-gated Ca <sub>V</sub> 2.1 channels causing familial hemiplegic migraine 1 increase the susceptibility for cortical spreading depolarization and seizures and worsen outcome after experimental traumatic brain injury

2021-12-02

Abstract excerpt

Patients suffering from familial hemiplegic migraine type 1 (FHM1) may have a disproportionally severe outcome after head trauma, but the underlying mechanisms are unclear. Hence, we subjected knock-in mice carrying the severer S218L or milder R192Q FHM1 gain-of-function missense mutation in the CACNA1A gene that encodes the α 1A subunit of neuronal voltage-gated CaV2.1 (P/Q-type) calcium channels and their wild...

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Literature Corpus work: 032d6815-d66b-5c95-aa2a-b1b82da43ba9
DOI: 10.1101/2021.11.30.470522

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