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Article

High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.

Annals of neurology - 1 Jan 2010

van den Maagdenberg Arn M J M, Pizzorusso Tommaso, Kaja Simon, Terpolilli Nicole, Shapovalova Maryna, Hoebeek Freek E, Barrett Curtis F, Gherardini Lisa, van de Ven Rob C G, Todorov Boyan, Broos Ludo A M, Tottene Angelita, Gao Zhenyu, Fodor Mariann, De Zeeuw Chris I, Frants Rune R, Plesnila Nikolaus, Plomp Jaap J, Pietrobon Daniela, Ferrari Michel D

Abstract excerpt

OBJECTIVE: The CACNA1A gene encodes the pore-forming subunit of neuronal Ca(V)2.1 Ca2+ channels. In patients, the S218L CACNA1A mutation causes a dramatic hemiplegic migraine syndrome that is associated with ataxia, seizures, and severe, sometimes fatal, brain edema often triggered by only a mild...

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Identifiers

PMID: 20186955
DOI: 10.1002/ana.21815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20186955-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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