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Article

CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis.

Journal of physiology, Paris - 1 Jan 2012

Uchitel Osvaldo D, Inchauspe Carlota González, Urbano Francisco J, Di Guilmi Mariano N

Abstract excerpt

Studies on the genetic forms of epilepsy, chronic pain, and migraine caused by mutations in ion channels have given crucial insights into the molecular mechanisms, pathogenesis, and therapeutic approaches to complex neurological disorders. In this review we focus on the role of mutated CaV2.1 (i.e., P/Q-type) voltage-activated Ca2+ channels, and on the ultimate consequences that mutations causing familial...

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Identifiers

PMID: 22074995
DOI: 10.1016/j.jphysparis.2011.10.004

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