Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant mice

9 Jan 2024

Abstract excerpt

Mechanisms underlying the migraine aura are incompletely understood, which to large extent is related to a lack of models in which cortical spreading depolarization (CSD), the correlate of the aura, occurs spontaneously. Here, we investigated electrophysiological and behavioural CSD features in freely behaving mice expressing mutant CaV2.1 Ca2+ channels, either with the milder R192Q or the severer S218L missense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Migraine and Headache Studies
Share to Sympathectomy and Hyperhidrosis Treatments
Share to Vestibular and auditory disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38211710
DOI: 10.1016/j.nbd.2024.106405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant micePMID 38211710Read ↗

First FHM3 mouse model shows spontaneous cortical spreading depolarizationsSemantic proximity Read ↗

Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraineSemantic proximity Read ↗

High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.Semantic proximity Read ↗

Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.Semantic proximity Read ↗

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.Semantic proximity Read ↗

CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury.Semantic proximity Read ↗

Mutated neuronal voltage-gated Ca <sub>V</sub> 2.1 channels causing familial hemiplegic migraine 1 increase the susceptibility for cortical spreading depolarization and seizures and worsen outcome after experimental traumatic brain injurySemantic proximity Read ↗

CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis.Semantic proximity Read ↗

Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice.Semantic proximity Read ↗

Cortical Spreading Depression Can Be Triggered by Sensory Stimulation in Primed Wild Type Mouse Brain: a Mechanistic Insight to Migraine Aura GenerationSemantic proximity Read ↗

Spreading depression and the clinical correlates of migraine.Semantic proximity Read ↗

Genetic mouse models of migraineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.