Article
A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression.
Neuron - 4 Mar 2004
van den Maagdenberg Arn M J M, Pietrobon Daniela, Pizzorusso Tommaso, Kaja Simon, Broos Ludo A M, Cesetti Tiziana, van de Ven Rob C G, Tottene Angelita, van der Kaa Jos, Plomp Jaap J, Frants Rune R, Ferrari Michel D
Abstract excerpt
Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels. We generated a knockin mouse model carrying the human pure FHM-1 R192Q mutation and found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.