Article
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.
Annals of neurology - 1 Aug 2015
Eikermann-Haerter Katharina, Arbel-Ornath Michal, Yalcin Nilufer, Yu Esther S, Kuchibhotla Kishore V, Yuzawa Izumi, Hudry Eloise, Willard Carli R, Climov Mihail, Keles Fatmagul, Belcher Arianna M, Sengul Buse, Negro Andrea, Rosen Isaac A, Arreguin Andrea, Ferrari Michel D, van den Maagdenberg Arn M J M, Bacskai Brian J, Ayata Cenk
Abstract excerpt
OBJECTIVE: Migraine is among the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated CaV 2.1 calcium channels. FHM1 mice carry human pathogenic mutations in the α1A subunit of CaV 2.1 channels and are highly susceptible to cortical spreading depression (CSD), the electrophysiologic event...
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