Article
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.
The Journal of clinical investigation - 1 Jan 2009
Eikermann-Haerter Katharina, Dileköz Ergin, Kudo Chiho, Savitz Sean I, Waeber Christian, Baum Michael J, Ferrari Michel D, van den Maagdenberg Arn M J M, Moskowitz Michael A, Ayata Cenk
Abstract excerpt
Familial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of migraine with aura that is associated with hemiparesis. As with other types of migraine, it affects women more frequently than men. FHM1 is caused by mutations in the CACNA1A gene, which encodes the alpha1A subunit of Cav2.1 channels; the R192Q mutation in CACNA1A causes a mild form of FHM1, whereas the S218L mutation causes a severe,...
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