Article
Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma.
The Journal of biological chemistry - 6 May 2005
Tottene Angelita, Pivotto Francesca, Fellin Tommaso, Cesetti Tiziana, van den Maagdenberg Arn M J M, Pietrobon Daniela
Abstract excerpt
Mutation S218L in the Ca(V)2.1 alpha(1) subunit of P/Q-type Ca(2+) channels produces a severe clinical phenotype in which typical attacks of familial hemiplegic migraine (FHM) triggered by minor head trauma are followed, after a lucid interval, by deep (even fatal) coma and long lasting severe cerebral edema. We investigated the functional consequences of this mutation on human Ca(V)2.1 channels expressed in...
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