Article

Classes of ITD predict outcomes in patients with AML treated with <i>FLT3</i> inhibitors

2018-05-14

Abstract excerpt

Recurrent internal tandem duplication (ITD) mutations are observed in various cancers including acute myeloid leukemia (AML). ITD mutations of Fms-like tyrosine kinase 3 ( FLT3 ) receptor increase kinase activity, and are associated with poor prognostic outcomes. Currently, several small-molecule FLT3 inhibitors (FLT3i) are in clinical trials for targeted therapy of high-risk FLT3-ITD-positive AML. However, the...

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Literature Corpus work: 031cb267-8fba-56f8-b9c3-cb2de0ed04fc
DOI: 10.1101/322354

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