Article
Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.
Cancer research - 1 Oct 2001
Whitman S P, Archer K J, Feng L, Baldus C, Becknell B, Carlson B D, Carroll A J, Mrózek K, Vardiman J W, George S L, Kolitz J E, Larson R A, Bloomfield C D, Caligiuri M A
Abstract excerpt
The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age with primary AML and normal cytogenetics, who received uniform high-dose therapy and found FLT3 ITD in 23 (28%) patients. When the 23 FLT3 ITD+ cases were compared with the 59 cases with wild-type (WT) FLT3, disease-free survival (DFS) was inferior (P =...
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