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Article

Accurate Detection and Quantification of FLT3 Internal Tandem Duplications in Clinical Hybrid Capture Next-Generation Sequencing Data.

The Journal of molecular diagnostics : JMD - 1 Oct 2021

Tung Jack K, Suarez Carlos J, Chiang Tsoyu, Zehnder James L, Stehr Henning

Abstract excerpt

FLT3 internal tandem duplications (ITDs) are found in approximately one-third of patients with acute myeloid leukemia and have important prognostic and therapeutic implications that have supported their assessment in routine clinical practice. Conventional methods for assessing FLT3-ITD status and allele burden have been primarily limited to PCR fragment size analysis because of the inherent difficulty in...

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Source

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Identifiers

PMID: 34363960
DOI: 10.1016/j.jmoldx.2021.07.012
PMCID: PMC8527870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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