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Article

Comprehensive review and evaluation of computational methods for identifying FLT3-internal tandem duplication in acute myeloid leukaemia.

Briefings in bioinformatics - 2 Sept 2021

Yuan Danyang, He Xiaoyu, Han Xinyin, Yang Chunyan, Liu Fei, Zhang Shuying, Luan Haijing, Li Ruilin, He Jiayin, Duan Xiaohong, Wang Dongliang, Zhou Qiming, Gao Sujun, Niu Beifang

Abstract excerpt

Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3-ITD) constitutes an independent indicator of poor prognosis in acute myeloid leukaemia (AML). AML with FLT3-ITD usually presents with poor treatment outcomes, high recurrence rate and short overall survival. Currently, polymerase chain reaction and capillary electrophoresis are widely adopted for the clinical detection of FLT3-ITD, whereas the...

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PMID: 33851200
DOI: 10.1093/bib/bbab099

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