Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.

Blood - 17 Sept 2009

Kayser Sabine, Schlenk Richard F, Londono Martina Correa, Breitenbuecher Frank, Wittke Kerstin, Du Juan, Groner Silja, Späth Daniela, Krauter Jürgen, Ganser Arnold, Döhner Hartmut, Fischer Thomas, Döhner Konstanze

Abstract excerpt

To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3-ITD-positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3-ITD-mutated patients. All patients were treated on 3 German-Austrian AML Study Group protocols. Thirty-four of the 241 patients had more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Gene Duplication

Share to Leukemia, Myeloid, Acute

Share to Mutagenesis, Insertional

Share to Protein-Tyrosine Kinases

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 19602710
DOI: 10.1182/blood-2009-03-209999

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.PMID 19602710Read ↗

Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study resultsSemantic proximity Read ↗

Medium-sized FLT3 internal tandem duplications confer worse prognosis than short and long duplications in a non-elderly acute myeloid leukemia cohort.Semantic proximity Read ↗

Diversity of the juxtamembrane and TKD1 mutations (exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data.Semantic proximity Read ↗

FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B studySemantic proximity Read ↗

Impact of FLT3-ITD length on prognosis of acute myeloid leukemiaSemantic proximity Read ↗

Targeting FLT3 mutations in AML: review of current knowledge and evidenceSemantic proximity Read ↗

Advances in the pathogenesis of FLT3 -mutated acute myeloid leukemia and targeted treatments.Semantic proximity Read ↗

FLT3-ITD and its current role in acute myeloid leukaemia.Semantic proximity Read ↗

FLT3-ITD mutations in acute myeloid leukaemia - molecular characteristics, distribution and numerical variation.Semantic proximity Read ↗

Comment on Association of FLT3-internal duplication length with overall survival in acute myeloid leukemia: a systematic review and meta-analysis.Semantic proximity Read ↗

Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patternsSemantic proximity Read ↗

FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.