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Article

Visualizing formation of the active site in the mitochondrial ribosome.

eLife - 5 Oct 2021

Chandrasekaran Viswanathan, Desai Nirupa, Burton Nicholas O, Yang Hanting, Price Jon, Miska Eric A, Ramakrishnan V

Abstract excerpt

Ribosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of the conserved peptidyl transferase center (PTC) of the human mitochondrial ribosome. The conserved GTPase GTPBP7 regulates the correct folding of 16S ribosomal RNA (rRNA) helices and ensures 2'-O-methylation of the PTC base U3039....

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Identifiers

PMID: 34609277
DOI: 10.7554/eLife.68806
PMCID: PMC8492066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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