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Multi-trait analysis reveals risk loci for heart failure and the shared genetic etiology with blood lipids, blood pressure, and blood glucose.

Cell reports - 24 Sept 2024

Zhu Yanchen, Wang Yahui, Cui Zhaorui, Liu Fani, Hu Chunyu, Hu Jiqiang

Abstract excerpt

Phenotypic associations have been reported between heart failure (HF) and blood lipids (BLs), blood pressure (BP), and blood glucose (BG). However, the shared genetic etiology underlying these associations remains incompletely understood. Conducting a large-scale multi-trait association study for HF with these traits, we discovered 143 previously unreported genomic risk loci for HF. Results showed that 46, 35,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39276349
DOI: 10.1016/j.celrep.2024.114735

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