Article

Within-ejaculate sperm selection in humans acts against molecular signatures of age-related disease

2024-10-09

Abstract excerpt

The germline is widely regarded as a checkpoint against the inheritance of damaged genomes, yet the mechanisms that could enact such filtering remain poorly resolved. Of the millions of sperm in a human ejaculate, only one fertilises the egg, creating a strong opportunity for selection among gametes. Combining within-ejaculate selection on sperm quality with whole-genome sequencing and proteomics in healthy donors...

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Literature Corpus work: 02853d68-26b0-5383-8b60-2e1d8a3e8f1e
DOI: 10.1101/2024.10.08.617222

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