Article
Sperm sequencing reveals extensive positive selection in the male germline.
Nature - 1 Nov 2025
Neville Matthew D C, Lawson Andrew R J, Sanghvi Rashesh, Abascal Federico, Pham My H, Cagan Alex, Nicola Pantelis A, Bayzetinova Tetyana, Baez-Ortega Adrian, Roberts Kirsty, Lensing Stefanie V, Widaa Sara, Alcantara Raul E, García María Paz, Wadge Sam, Stratton Michael R, Campbell Peter J, Small Kerrin, Martincorena Iñigo, Hurles Matthew E, Rahbari Raheleh
Abstract excerpt
Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In humans, positive selection of driver mutations during spermatogenesis can increase the birth prevalence of certain developmental disorders1-3. Until recently, characterizing the extent of this selection in sperm has been limited by the error rates of sequencing technologies. Here we used the duplex sequencing method...
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