Article

Sperm sequencing reveals extensive positive selection in the male germline

2024-11-01

Abstract excerpt

Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In humans, positive selection of driver mutations during spermatogenesis is known to increase the birth prevalence of certain developmental disorders. Until recently, characterising the extent of this selection in sperm has been limited by the error rates of sequencing technologies. Using the duplex sequencing method NanoSe...

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Literature Corpus work: fa9e4f4f-ec62-5531-8fc2-fc0e4afb9cc1
DOI: 10.1101/2024.10.30.24316414

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