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Article

The impact of paternal age on new mutations and disease in the next generation.

Fertility and sterility - 1 Dec 2022

Wood Katherine A, Goriely Anne

Abstract excerpt

Advanced paternal age is associated with an increased risk of fathering children with genetic disorders and other adverse reproductive consequences. However, the mechanisms underlying this phenomenon remain largely unexplored. In this review, we focus on the impact of paternal age on de novo mutations that are an important contributor to genetic disease and can be studied both indirectly through large-scale...

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Identifiers

PMID: 36351856
DOI: 10.1016/j.fertnstert.2022.10.017
PMCID: PMC10909733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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