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Article

Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

1 Dec 2019

Abstract excerpt

BACKGROUND: The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an excellent opportunity to trace the direct, transgenerational transmission of these signals. RESULTS: We utilized the...

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PMID: 31856899
DOI: 10.1186/s13072-019-0323-4

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